Synthesis and Spectroscopic Characterisation of O-Chlorocarbonyl Derivatives of Bile Acid Methyl Esters

Abstract

The synthesis of O-chlorocarbonyl derivatives of a series of bile acid methyl esters is described. The steroidal chloroformate esters were prepared by the reaction of the respective hydroxy derivatives with triphosgene–pyridine in benzene at 25 °C. The O-chlorocarbonyl derivatives were characterised by spectroscopic methods.