Abstract
N-Oxidobenzamide derivatives are powerful metal ion chelators. It is used as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, Alzheimer’s diseases and more. In this study, Copper (ll) (SRC1 and SRC3) and Cadmium (ll) (SRC2 and SRC4) complexes were synthesized from potassium N-Oxidobenzamide derivative ligands and they were characterized by using various techniques such as Infra-Red spectra, electronic spectra, melting point and conductivity measurements. The electronic spectral study and the melting point analysis revealed that the ligands are coordinated to the metal centre. IR and conductivity analyses confirm the coordination of hydroxamate ions to the metal centre as O, O-bidentate mode via the hydroxyl oxygen and the carbonyl oxygen atoms of the ligands. The proposed molecular structures for the newly formed complexes are also given.
Highlights
Hydroxamic acids are naturally occurring or synthetic weak organic acids and produce hydroxamate ion [1, 2]
The conductivity measurements were made in DMF solution and all complexes are found to be non-electrolytes
This was further confirmed by Thin Layer Chromatography (TLC)
Summary
Hydroxamic acids are naturally occurring or synthetic weak organic acids and produce hydroxamate ion [1, 2]. They are preferably named as N-hydroxy amides’. The most important application of N-Oxidobenzamide is as good metal ion chelators [6]. This kind of compounds and their derivatives find many applications in chemistry and biology and have been the subject of many experimental investigations [7, 8]. Saranya Sathiyavasan et al.: Synthesis and Spectroscopic Analysis of the Nature of Coordination modes of Ligands in Copper (ll) and Cadmium (ll) Complexes of Two N-Oxidobenzamide Derivatives
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