Abstract
Five fatty ester derivatives of podophyllotoxin have been prepared by reacting the corresponding fatty acids with the hydroxy group of podophyllotoxin in the presence of dimethylaminopyridine and N, N-dicyclohexylcarbodiimide. The fatty acids incorporated are: 9,12-epoxy-9,11-octadecadienoic acid, octadec-11 E-en-9-ynoic acid, 11,12- E-epoxy-octadec-9-ynoic acid, octadeca-9 Z,11 E-dienoic acid and 9,10-dibromooctadecanoic acid. The average yield of esterification was >95% and the structures of the products were confirmed by a combination of nuclear magnetic resonance spectroscopic and mass spectrometric analyses.
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