Abstract
AB2-type amphiphilic (HPMC)2-PLA copolymers with various hydrophilic block lengths were synthesized using a three step procedure: ring-opening polymerization of L-lactide initiated by propynol, amination reduction of the aldehyde endgroup of HPMC, and thiol-click reaction. The resulted copolymers were characterized by NMR, DOSY-NMR, SEC and FT-IR. The cloud point (CP) was determined by UV–vis spectrometer. Data show that the HPMC block length has little effect on the Cp of the copolymers which is lower than that of HPMC. The self-assembly behavior of the copolymers was investigated from DLS, TEM, and critical micelle concentration (CMC) measurements. Spherical micelles are obtained by self-assembly of copolymers in aqueous solution. The micelle size and the CMC of copolymers increase with increasing HPMC block length. It is concluded that biobased and biodegradable (HPMC)2-PLA copolymers could be promising as nano-carrier of hydrophobic drugs.
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