Abstract
A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core–shell–corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
