Abstract
The aim of the present work is first to synthesis a magnetic chitosan hydrogel (chitosan ferrogel) using the blending method and second to study it rheological behavior. Magnetic components ( maghemite particles γ-Fe2O3 ) were synthesized via a simple chemical co-precipitation route also called Massart's procedure. Before being dispersed in chitosan network, γ-Fe2O3 particles were covered with a cationic polyelectrolyte (Polydiallyldimethylammonium chloride; PDADMAC) and the exact quantity required to cover the entire surface of maghemite particles was determined by Electrophoretic mobility. The successful functionalization of maghemite particles was confirmed by zeta potential measurement. The prepared ferrogel was gelified using glyoxal as crosslinking agent. The effect of continuous magnetic field on rheological properties of the elaborated ferrogel was studied, under controlled temperature before and after the gelation process, using a rotating rheometer fitted with a new magneto-rheological cell. Moreover the influence of iron oxide content on the gelation time of magnetic hydrogel was studied by comparing two ferrogels with different maghemite particles content. Flow and viscoelastic measurements showed that applying magnetic field facilitates the formation of a new structure (column-like arrangements), which was confirmed by in situ optical microscopic observation. Kinetic study was investigated by mechanical spectroscopy and demonstrates that the gelation time depends on both iron oxides content and magnetic field.
Highlights
Combining magnetic oparticles and biopolymers have attracted increasing interest since they produce highly efficient magnetic responsive hydrogels and offer more options for medicine and pharmacy such as drug delivery system [2], tissue engineering [3], cancer therapy [4] and many other applications [5, 6] due to their mechanism for shape change under external magnetic field
Before being dispersed in chitosan network, γ-Fe2O3 particles were covered with a cationic polyelectrolyte (Polydiallyldimethylammonium chloride; PDADMAC) and the exact quantity required to cover the entire surface of maghemite particles was determined by Electrophoretic mobility
Kinetic study was investigated by mechanical spectroscopy and demonstrates that the gelation time depends on both iron oxides content and magnetic field
Summary
Combining magnetic oparticles (e.g. maghemite γ-Fe2O3 , magnetite Fe3O4 or cobalt ferrite CoFe2O4 [1]) and biopolymers have attracted increasing interest since they produce highly efficient magnetic responsive hydrogels and offer more options for medicine and pharmacy such as drug delivery system [2], tissue engineering [3], cancer therapy [4] and many other applications [5, 6] due to their mechanism for shape change under external magnetic field. In addition they possess a remote reaction a non-contact action. Liu et al [8] reviewed the fabrication process of magnetic hydrogels and revealed the main factors capable of affecting its properties, including the type and concentration of both hydrogels and magnetic nanoparticles, size distribution and uniformity of magnetic component within the cross-linked network
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