Abstract
Amides and esters of aziridine-2-carboxylic acid were synthesized by the reaction of 1,1,1-trimethyl-2-(2-carboxyethyl)hydrazinium derivatives with an anion-exchange resin or with sodium hydride. Enamines were obtained from 1,1,1-trimethyl-2-[1,2-bis(alkoxycarbonyl)ethyl]hydrazinium salts and basic agents. Methods for the synthesis of amides of aziridine-2,2- and aziridine-2,3-dicarboxylic acids were developed. The stereochemistry of the esters and amides of aziridine-2,3-dicarboxylic acids was established. Dialkylcarbamoylaziridines were reduced with lithium aluminum hydride to 2-(N,N-dialkylaminomethyl)aziridines. The reduction of esters of aziridine-2-carboxylic acid and their functionally substituted derivatives leads to the formation of 2-hydroxymethylaziridines. An O-silylation product was obtained by silylation of 2-hydroxymethylaziridine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
