Synthesis and reactivity of pyrazolo-pyridone ring, an understudied heteroaromatic scaffold

Flavio Emery,A Ganesan,James Dale,Paulo Eliandro Da Silva Júnior

doi:10.5151/chempro-15bmos-bmos2013_2013915143915

Abstract

The chemical structural space of all possible compounds is vast, with more than 10 compounds with molecular weights below 500 Da. Heteroaromatic rings are common in bioactive molecules and both medicinal and agro chemists have exploited these scaffolds to provide high value materials, for example Glivec, an anti cancer drug, and Exjade to treat iron overload. However, only a small fraction of the heteroaromatic space is currently exploited for drug discovery, and has established synthetic routes to access them, supporting a scenario in which is shown the disclosure of new heterocyclic skeletons follows a rate of 5-10 per year. The main scope of this work is to study the synthesis of underexplored heterocyclic scaffold, based on a recent computational study, which listed interesting yet under represented heterocyclic skeletons with drug discovery potential.

Highlights

The chemical structural space of all possible compounds is vast, with more than 1062 compounds[1] with molecular weights below 500 Da
The synthesis of the target heterocycles had been achieved by an N-acyl-Nnitroso rearrangement approach (Scheme 1).[3]
I want to acknowledge and thank the CAPEs for the scholarship, besides FAPESP, CNPq, the Novartis D&I Office

Summary

Introduction

The chemical structural space of all possible compounds is vast, with more than 1062 compounds[1] with molecular weights below 500 Da. The selected scaffold is a pyrazolo-pyridone 1, it is a 6,5 fused ring system with mixed electronic characteristics.

Results

Conclusion