Abstract
Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC 6H 4)Ph 2P NR with [AuCl 4] − gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl 2AuC 6H 4)Ph 2P NR [R = (R,S)- or (S)-CHMePh, p-C 6H 4F, t Bu], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl 2AuC 6H 4)Ph 2P NPh with PPh 3 results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh 3)AuC 6H 4)Ph 2P NPh] +, indicating that the P N donor is strongly bonded to the gold centre.
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