Synthesis and radioprotective effects of derivatives of thiadiazoles, dithiolidenes, and their selenium analogs

Abstract

Derivatives of the sulfur-containing five-membered heterocyclic ring compounds, the 1,2,3-thiadiazoles, 1,3,4-thiodiazole, and 1,3-dithio-2-ylidenes, have a wide spectrum of biological activity. Studies of the radioprotective effects of sulfur-containing five-membered heterocyclic ring compounds have revealed such properties among a number of thiazoles. A number of heterocyclic selenium derivatives have also been shown to have radioactive properties. We report here the synthesis of 4-aryl-1,2,3-thia(selena)diazoles, 2-dialkylamino-1,3,4-thia(selena)diazolines, 2-benzylidene-1,3,4-thia(selena)diazolines, and 2-arylidene-1,3-dithio(selena)ols and the study of the toxic and radioprotective properties of these heterocyclic compounds on mice. These studies have demonstrated a relationship between the toxicity of the heterocyclic compounds and the presence of a selenium atom in the ring, without finding radioprotective properties among these five-membered, sulfur-, selenium-, and nitrogen-containing hetercyclic ring compounds, with the exception of 2-arylidene-1,3-dithiol. 9 refs., 3 tabs.