Abstract
The paper contains the results obtained in grafting the acyl-thiosemicarbazide on the holder molecule 5-nitro-benzimidazol-2-sulfonyl-acetic acid by oxidation reaction of 5-nitro-benzimidazol-2-yl-mercapto-acetic acid, then passed to the corresponding sulfonyl hydrazide. Acyl-thiosemicarbazides containing the sulfonyl group were obtained. The chemical structure of the newly obtained compounds was confirmed by spectral analysis (FT-IR, 1H-NMR). This article aims with spectral and quantum-chemical characterization of three new thiosemicarbazides with potential tuberculostatic action. The reaction way, the main IR and NMR peaks and the quantum-mechanical parameters, computed with Spartan’14 program are estimated. The tuberculostatic of action is analyzed compared with reference drug isoniazid.
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