Synthesis and quality control testing of 32P labeled ion exchange resin microspheres for radiation therapy of hepatic neoplasms

Abstract

Commercial cation exchange resin beads (200–400mesh) are separated into narrow particle size ranges by sieving and differential sedimentation. These microspheres are converted into the chromic form by reaction with Cr(NO 3) 3, labeled with 20 mCi 32P phosphate by exchange at pH 2–4, and converted to a stable product at pH9. Chemical stability and biological behavior of these microspheres suspended in physiological saline is measured before administration through a hepatic artery catheter for radiation therapy of the liver and hepatic neoplasms.