Abstract
Abstract[2‐13C]‐5‐Fluoropyrimidine‐2,4(1H,3H)‐dione ([2‐13C]‐5‐fluorouracil or [2‐13C]‐5‐FU) is a potential diagnostic agent for measuring 5‐FU‐induced toxicity in cancer patients. It was prepared and purified with isotopic and chemical purity of>99% on a multigram scale in a two‐step synthesis from [13C]‐urea. Preparative separation of [2‐13C]‐FU and [2‐13C]‐uracil was carried out by automated medium pressure silica gel column chromatography. The method is applicable to a broader range of 5‐FU isotopic analogs derived from labeled uracil. Copyright © 2011 John Wiley & Sons, Ltd.
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