Synthesis and psychotropic properties of bis(2-thenylidene)diamines and their silyl derivatives

Abstract

The condensation of diamines with the corresponding aldehydes gave bis(2-thenylidene)diamines and their silyl derivatives. The structure of the compounds has been confirmed by their PMR spectra. It has been shown that the introduction of the trimethylsilyl group increases the toxicity, prolongs the hexenal narcosis and the antihypoxy activity, has a positive effect on the memory processes, and has no influence on the coordination of movements, the muscle tone, and the body temperature. All compounds possess an antialcohol activity, whereby the silyl derivatives have the stronger one.