Abstract
Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The hydrogel surface morphology and composition were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The thermal stability was analyzed by thermogravimetric analysis (TGA). The swelling properties and pH, temperature, and salt sensitivities of KPAsp, KPAsp/PVA semi-interpenetrating polymer network (semi-IPN), and KPAsp/PVA IPN hydrogels were also investigated. All of the three hydrogels showed ampholytic pH-responsive properties, and swelling behavior was also extremely sensitive to the temperature, ionic strength, and cationic species. Finally, the drug controlled release properties of the three hydrogels were evaluated and results indicated that three hydrogels could control drug release by external surroundings stimuli. The drug controlled release properties of KPAsp/PVA IPN hydrogel are the most outstanding, and the correlative measured release profiles of salicylic acid at 37°C were 32.6 wt% at pH = 1.2 (simulated gastric fluid) and 62.5 wt% at pH = 7.4 (simulated intestinal fluid), respectively. These results indicated that KPAsp/PVA IPN hydrogels are a promising carrier system for controlled drug delivery.
Highlights
Hydrogels are natural or synthetic hydrophilic networks of polymer, which have strong ability to retain water and other biological fluids, while preserving their shapes [1, 2]
Novel biodegradable KPAsp/poly(vinyl alcohol) (PVA) Interpenetrating polymer network (IPN) hydrogel was successfully synthesized in an aqueous system by a simple onestep method
Homogeneous network structure of IPN hydrogel was obtained in uniform reaction system
Summary
Hydrogels are natural or synthetic hydrophilic networks of polymer, which have strong ability to retain water and other biological fluids, while preserving their shapes [1, 2]. Over the last two decades, stimulus-responsive hydrogels have been extensively studied on their reversible volume changes controlled by external stimuli, such as pH, temperature, solvents, ionic strength, and ultrasonic sound [3, 4]. Their porosity and responsiveness to the environment are vital in the biological pharmaceutical applications, especially for drug delivery. Because thermosensitive hydrogels dissolve in solutions at low temperature, they have attracted attention They can be separated from solution if the lower critical solution temperature is lower than the environment temperature [8,9,10]. These hydrogels have been broadly applied to the development of novel drug carriers, which exhibited controlled-release characteristics [11,12,13,14]
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