Synthesis and Properties of Organo-Inorganic Composites Based on Daunomycin, Polyvinylpyrrolidone, and Selenium Nanoparticles

Abstract

Two procedures for preparing organo-inorganic composites based on daunomycin, polyvinylpyrrolidone, and selenium nanoparticles were developed with the aim of preparing water-soluble nontoxic derivatives of daunomycin antitumor antibiotic. The first procedure consists in preliminary stabilization of selenium nanoparticles with polyvinylpyrrolidone, followed by addition of daunomycin, and the second procedure, in preliminary formation of a complex of daunomycin with polyvinylpyrrolidone, followed by selenium reduction. As shown by optical spectroscopy and by dynamic and static light scattering, the synthesis procedure does not influence the weight-average molecular mass of the synthesized composites, but influences the structural organization and size of particles and, correspondingly, their mobility. The composite prepared by the second procedure shows promise for antitumor therapy.