Abstract
The copolymer P(VA-AA) was synthesized by free radical solution polymerization of vinyl acetate (VAc) and acrylic acid (AA) and subsequent saponification. It was found that by increasing the mass ratio of AA, the content of –COOH groups in PVA copolymers increased, while \( \overline{Mw} \) increased with a broader molecular weight distribution. The carboxylated hydrogels of P(VA-AA) were prepared by the freezing/thawing method for wound dressings. By increasing the mass ratio of AA, the storage modulus (G’) and mechanical strength decreased, resulting from the reduced physical cross-link density (Dpc) and looser network structure. The value of G’ was larger than G” and practically independent of frequency, and tanδ values approached 0 for all hydrogels, indicating a dominant elastic property and strong network structure. Introduction of AA onto PVA chains significantly improved the swelling rate constant k and equilibrium swelling ratio, and most of the water in the hydrogel was in the form of free water. The Higuchi model was the most suitable model for describing crystal violet (CV) release kinetics from PVA hydrogels, and the dissolution constant k was higher for the carboxylated PVA hydrogel than that of the pure one.
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