Abstract
Trimers of 2', 5'-oligoadenylic acids bearing 2'-terminal 8-bromo- or 8-hydroxyadenosine have been synthesized by the phosphotriester method. Some properties of these compounds were studied by circular dichroism (CD) spectroscopy. The 2', 5'-adenylate trimer, A2'p5'A2'p5'HOA (10a) was found to have a less stacked structure than the 2', 5'-adenylate trimers A2'p5'A2'p5'BrA (11) and A2'p5'A2'p5'A (10b).
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