Abstract
A new nitrido-188Re complex, 188ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using 188ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about 12 hours. These results indicated that 188ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.
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