Abstract
The preparation of 3-cyano-4,6-diaryl-pyridin-2(1H)-ones 4a– h, calcium entry blockers related to diltiazem, is described starting from 1,3-diaryl-2-propen-1-ones 5. On preliminary pharmacological tests all compounds are active and some of them show calcium antagonistic activity superior or comparable to diltiazem.
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