Abstract
A
 A new series of bases of Schiff (H2-H4) derived from phthalic anhydrideweresynthesized. These Schiff bases were prepared by the reaction of different amines (tyrosine methyl ester, phenylalanine methyl ester, and isoniazid) with the phthalimide derived aldehyde with the aid of glacial acetic acid or triethylamine ascatalysts. All the synthesized compounds were characterized by (FT-IR and 1HNMR) analyses and were in vitro evaluated for their antimicrobial activity against six various kinds of microorganisms. All the synthesized compounds had been screened for their antimicrobial activity against two Gram-positive bacteria “Staph. Aureus, and Bacillus subtilis”, two Gram-negative bacteria “Escherichia coli, and Klebsiella pneumoniae”, and two fungi species “Candida tropicalis and Candida albicans” using concentrations of 62.5, 125 and 250 µg\mLof derivative in dimethyl sulfoxide(DMSO). All the synthesized compounds showed no activity at all against Gram-positive bacteria, for Gram-negative bacteria and fungi they showed moderate or no activity except compound H1revealedhigh antifungal activityagainstCandida tropicalisat concentrations 125 and 250 µg\ mL.
 Keywords: Schiff base, phthalic anhydride, antimicrobial.
Highlights
The development of multidrug microbialPhthalimide derivatives have a structural resistance is the main challenge that modern core (–CO-N(R)- CO-) and an imide ring which scientists have so far been facing in the recent confer a biological activity to them
The Phthalimide subunit has been designed as a hybrid with other molecules to give either synergistic, additive or new biological activity[11,12] .On another hand, it was found that the Schiff bases are of great benefit for the synthesis of various bioactive medicinal compounds from the primary amine
The synthetic pathway started by the preparation of aldehyde of phthalimide compound (H1) through imide bond formation using glacial acetic acid as solvent and catalyst
Summary
Phthalimide derivatives have a structural resistance is the main challenge that modern core (–CO-N(R)- CO-) and an imide ring which scientists have so far been facing in the recent confer a biological activity to them. Transcriptase Inhibitor[7], as protective agent[8], as encouraged hard work investigations in the fields of an antimicrobial agent using Schiff base principle[9], natural and synthetic chemistry, to discover new [10]&(11).The structural feature of the five-membered drug classes having many efficient therapeutic ring shows they are hydrophobic and this enhances profiles[1] The Phthalimide subunit has been designed as a hybrid with other molecules to give either synergistic, additive or new biological activity[11,12] .On another hand, it was found that the Schiff bases are of great benefit for the synthesis of various bioactive medicinal compounds from the primary amine They possess antimalarial, anticancer, antimicrobial, antioxidant, anticonvulsant and anti-inflammatory characters[13]. No research work linked isoniazid with phthalimide moiety through Schiff base has been reported
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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