Abstract
Three hydroxamic acids and seven N-formyl hydroxylamine derivatives containing oxazole ring have been designed and synthesized. The structures of target compounds were characterized on the basis of spectral (FT-IR, 1H NMR, and HRMS) analysis. All the final synthesized compounds were evaluated in vitro against Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Pseudomonas aeruginosa. Among them, 10a exhibited good activity against E. coli compared with the reference agent ciprofloxacin hydrochloride.
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