Synthesis and physicochemical properties of keto analogs of pyridoxal and their derivatives

Abstract

1. We synthesized a number of keto analogs of pyridoxal by the condensation of 4-methyl-5-propoxyoxazole with various dienophiles. 2. A study was made of the UV spectra of the obtained analogs, the reaction rate with phenylhydrazine was studied, and a conclusion was made regarding the role of the electronic and geometric state of the carbonyl group of pyridoxal 5′-phosphate in the enzymatic catalysis process.