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Abstract
The present study describes a novel strategy to covalently immobilize genes onto inert PLGA films via -CONH-cross-links. PLGA with functional carboxylic acid groups was synthesized using free-radical grafting maleic anhydride (MA) groups onto the polymer backbone. Cationic PEI/DNA complexes were successfully immobilized onto the functional PLGA films and characterized by ATR-FTIR and SEM analysis. We conclude that robust PLGA with functional carboxylic groups is a suitable platform for localized gene delivery.
Published Version
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