Synthesis and physico-chemical characterization of fluoride (F)- and silver (Ag)-substituted sol-gel mesoporous bioactive glasses

Saeid Kargozar,Masoud Mozafari,Francesco Baino,Sara Banijamali

doi:10.1515/bglass-2019-0015

Abstract

Abstract Synthesis and use of novel compositions of bioactive glasses (BGs) for hard tissue engineering are of important significance in the biomedical field. In this study, we successfully synthesized a series of 58S-based BGs containing fluoride (F−) and silver (Ag+) ions through a sol-gel method for possible use in bone/dental regeneration and antibacterial strategies. Characterizations of samples were performed by using thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), textural analysis (N2 adsorption-desorption), and morphological observations by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The obtained data revealed that the fabricated BGs are in a glassy state before incubation in the Kokubo’s simulated body fluid (SBF), and an apatite-like layer is formed on their surface after 7 days of immersion in SBF. The size of the glass particles was in the nano-range (about 100 nm or below), and their pore size was in the mesoporous range (15-25 nm). These early results suggest that the F- and Ag-doped glasses show promise as multifunctional bioactive materials for bone/dental tissue engineering.

Highlights

Received Aug 25, 2019; revised Dec 06, 2019; accepted Dec 06, 2019 AbstractSynthesis and use of novel compositions of bioactive glasses (BGs) for hard tissue engineering are of important significance in the biomedical field
As it can be seen in the exemplary Thermogravimetric analysis (TGA) graph for 58S glass, there are three main weight losses in the temperature ranges of 40-180, 180-360, and 360-570∘C as a result of thermal removal of free water and alcohol, alkoxides groups, and decomposition of nitrates
The results obtained from the Brunauer–Emmett–Teller (BET) analysis of the synthesized glasses revealed a type IV isotherm of the Brunauer–Deming–Deming–Teller theory (BDDT) classification [36] for all the materials prepared

Summary

Introduction

Synthesis and use of novel compositions of bioactive glasses (BGs) for hard tissue engineering are of important significance in the biomedical field. We successfully synthesized a series of 58S-based BGs containing fluoride (F−) and silver (Ag+) ions through a sol-gel method for possible use in bone/dental regeneration and antibacterial strategies. The size of the glass particles was in the nano-range (about 100 nm or below), and their pore size was in the mesoporous range (15-25 nm). These early results suggest that the F- and Ag-doped glasses show promise as multifunctional bioactive materials for bone/dental tissue engineering

Methods

Results

Discussion

Conclusion