Abstract
The purposes of this research were to synthesize and characterize star-shaped poly lactide-co-glycolide-β-cyclo-dextrin (PLGA-β-CD) copolymer by reacting L-lactide, glycolide and β-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA-β-CD copolymer was confirmed with 1H-NMR, 13C-NMR and FT-IR spectra. Albumin as a model peptide drug was encapsulated within nanoparticles made of PLGA-β-CD with a modified double emulsion method. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the nanoparticles have the mean diameter within the range of 80 - 210 nm. Also they were almost spherical in shape. Effects of the experimental parameters, such as copolymer composition, copolymer concentration, and reaction temperature, on particular size and encapsulation efficiency were investigated.
Highlights
Therapeutic proteins have been recognized as a novel generation of drugs, mainly due to their highly specific activity [1,2]
As to the use of different biodegradable polymers, PLGA has been extensively used for preparation of nanoparticles due to its safety and physicochemical properties, as it is nontoxic, biodegradable and biocompatible [5,6]
To overcome demerits of PLGA, nanoparticles described above constructed novel composite nanoparticles, which were composed of biodegradable polymers [9]
Summary
Therapeutic proteins have been recognized as a novel generation of drugs, mainly due to their highly specific activity [1,2]. Biodegradable nanoparticles as drug delivery systems for proteins or peptides have become an extremely hot topic for decades; these nanoparticles are suitable alternatives for conventional dosage forms [3,4]. To overcome demerits of PLGA, nanoparticles described above constructed novel composite nanoparticles, which were composed of biodegradable polymers [9]. Alginate and chitosan were used to form double-walled nanocapsules [10,11]. This kind of nanocapsules gives protein a suitable nanoenvironment by dual hydrophilic protection and makes the initial release retarded [12]. The dual-walled nanocapsules can be more incorporated in PLGA by W/O emulsification, and the release profiles
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