Abstract
The usual treatment for tuberculosis is difficult by its long-term therapy, raised dosing frequency and adverse effects of anti-tuberculosis drugs. Anionic clays, also called layered double hydroxides are a class of hydrotalcite like structures having high compositional variety and being able to self-assembly in the presence of drug molecules. The work refers to the development of nanohybrid materials like delivery systems that intercalates isonicotinic acid hydrazide, known as isoniazid anti-tuberculosis drug, into layered structure of hydrotalcite compounds. Loaded drug molecules of isoniazid were proved to be released in a controlled way from the as synthesized nanostructure in a simulated buffer solution. The obtained sample was characterized by advanced techniques thus demonstrating the inclusion of isoniazid antibiotic between hydrotalcite sheets. These results revealed important expectations for further researches of these organic-inorganic nanocomposites for tuberculosis treatment.
Highlights
ELENA ARIELA BANU14, LETITIA DOINA DUCEAC2,5*, GETA MITREA1,6*, MADALINA IRINA CIUHODARU3,7*, DANIELA LUMINITA ICHIM2,8, IRINA MIHAELA CIOMAGA3,5, ROXANA ELENA BOGDAN GOROFTEI1,4, MARCU CONSTANTIN1,9, GINEL BACIU14 1University Dunarea de Jos, Faculty of Medicine and Pharmacy, 47 Domneasca Str., 800008, Galati, Romania 2Apollonia University of Iasi, Faculty of Medicine, Academician Ioan Haulica Institute of Researches, 2 Muzicii Str., 700399, Iasi, Romania 3Grigore T
This study reports the synthesis and characterization of a nanodelivery system based on layered double hydroxides for the treatment of tuberculosis by the intercalation of isoniazid into the ZnAlLDHs structure
XRD peaks show that the basal spacing was 12.01Å and 11.54Å being first reflection (003) for both ZnAlLDHs-INH1 and ZnAlLDHs-INH2 nanohybrids
Summary
Called layered double hydroxides are a class of hydrotalcite like structures having high compositional variety and being able to self-assembly in the presence of drug molecules. The work refers to the development of nanohybrid materials like delivery systems that intercalates isonicotinic acid hydrazide, known as isoniazid anti-tuberculosis drug, into layered structure of hydrotalcite compounds. Hydrotalcites appeared as biocompatible drug delivery systems with great features such as cost effective materials, easiness of preparation, possibility of loading various active molecules, release of the drugs in a controlled manner and biodegradability [6-
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