Abstract
We have synthesized two novel push–pull-type fluorescent 7-deazapurine nucleosides, CNZA and CNZG , and investigated their photophysical properties. In particular, CNZA was found to exhibit a remarkable solvatofluorochromicity (Δ λ fl.max = 60 nm). We incorporated CNZA into oligonucleotides and found that CNZA can form a stable base pair with both thymine and cytosine. Such environmentally sensitive fluorescent nucleosides have a potential as a fluorescence sensor for structural studies of nucleic acids.
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