Abstract
A series of 3-(4-antipyryl)-2-arylthiazolidin-4-one derivatives were synthesized and pharmacologically evaluated for antinociceptive, spasmolytic and cardiovascular activities. The presence of a methoxy-naphthyl or a substituted phenyl group in 2-position of the 4-thiazolidinone ring increased the antinociceptive and spasmolytic activities by 3–12-fold compared with antipyrine. The most potent were the o-methoxy naphthalene and the m-chlorobenzene derivatives. Furthermore, the compounds showed no local anaesthetic activity, but they induced slight decreases in the rabbit arterial blood pressure.
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