Abstract
Systematic build-up of the peptide chain in solution led to [2-p-fluorophenylalanine]deamino-1-carba-oxytocin which after purification by countercurrent distribution was obtained in the form of diastereoisomeric sulfoxides. The sulfoxides were separated by chromatography and reduced with hydrogen bromide and acetone to the corresponding sulfide. Uterotonic and galactogogic activity of all compounds was determined; the diastereoisomeric sulfoxides differed markedly in these activities.
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