Synthesis and pharmacological activity of salts of 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles

Abstract

New water-soluble 3-acetyl-2-R-9-dialkylaminoethylimidazo[1,2-a]benzimidazoles were synthesized on the basis of previously described structure-effect relationships among imidazobenzimidazole derivatives with high levels of hypotensive activity. All these compounds were studied in vitro in terms of a variety of types of pharmacological activity characteristic for this class of compounds, including antiarrhythmic, antiaggregant, antioxidant, hemorheological, K-opioid agonistic, hypotensive, spasmolytic, and adrenoblocking activities; their effects on cAMP phosphodiesterdase activity and physical exercise tolerance were also studied.