Synthesis and Pharmacological Activity of 1-(arylsulfonyl)-3,5-dialkyl-s-triazine-2,4,6-(1H, 3H,5H)-triones

Abstract

A series of five 1-(arylsulfonyl)-3,5-dialkyl-s-triazine-2,4,6-(1H,3H,5H)-triones was synthesized by the base-catalyzed reaction of arylsulfonamides with alkyl isocyanates. The compounds were tested for apomorphine antagonism in mice, diuretic activity in fasted rats, antiviral activity in mice, antiviral activity in infected cell cultures, CNS stimulant activity in mice, and hypoglycemic activity in rats. The only biological activity exhibited by these compounds was a slight tendency to lower blood sugar levels in glucose-primed, fasted rats. This activity may be attributable to their structural similarity to the sulfonylurea hypoglycemics.