Synthesis and pharmaceutical applications of Oxazine compounds derived from Pyronic, Salicylic, Antharanilic acids and Phenols

Harith M Al-Ajely Harith M Al-Ajely

doi:10.30574/ijsra.2021.2.2.0250

Abstract

It is well known from FDA reports that More than 75% of the heterocyclic compounds are drugs and 90 of heterocyclic compounds are cancer drugs. The nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. Most drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties, More over heterocyclic compounds are important class of organic chemistry due to their widely spread in nature. Also there are many route for their action and many mechanistic pathways for their preparation and different metabolic actions. This comes from the easily building or removal of any functional group within the molecules. Changing just on group cause to change the metabolic pathway of the drug action and site of attack of the desired target accordingly. This great characteristic value make them much more important in drug discovery programs of many researchers and also encouraged us and drew attentions of other researchers to develop new ways for their synthesis. As a result different pharmacological and medical applications. Oxazie compounds are sub branch of heterocyclic compounds. These compounds having two hetero atoms, Oxygen and nitrogen within their structures make them much more important toward therapeutic studies. We are here in our investigation will focus on the methodologies and the therapeutic action of the titled compounds as well as other various applications.

Highlights

The first time that pyrano oxazine compounds were synthesized in 1952 during the work of Elvidge, Al-rawi et-als [110] from the reaction of pyronic acid with thiocyanate, isothiocyanate or the self-condensation of malonyl chloride with the above thiocyanate or isothiocyanate
An over review of the literature concerning the title of this study, it was clear that there is much limited resources for the applications of pyranooxazine compounds may be due to difficult in functionalize the pyrano ring due to the selfcondensation of malonyl chloride in producing the pyronic acid so the oxazine ring moiety can be changed by functionalization which is limited because there is just two ways for getting ne functional group either by the addition to the C=N of the oxazine or substitution of the oxygen moiety but in our patent we introduce new functional group by the addition to the C=N group giving new oxazine having anti-cancer therapeutic applications
The national cancer institute (NCI) report has reviled that this compound has no toxic effect among the other oxazines from anthranalic acid precursors we found many but not too much pharmaceutical application concerning this type of compound

Summary

Introduction

The first time that pyrano oxazine compounds were synthesized in 1952 during the work of Elvidge, Al-rawi et-als [110] from the reaction of pyronic acid with thiocyanate, isothiocyanate or the self-condensation of malonyl chloride with the above thiocyanate or isothiocyanate. Some other researchers have prepared pyronooxazines from the self-condensation of malony chlorid with thiocyanate but here the product of the pyronooxazines was reacted with amino acid esters and results into the formation of biologically active compounds toward some microorganisms [17,18].

Results

Conclusion