Abstract

AbstractNovel alkyl thiophosphoramidate derivatives of nucleoside analogues (5) have been prepared by phosphochloridothioate chemistry. O‐Isopropyl 2′, 3′‐O‐isopropylidene uridine‐5′‐yl N‐thiophosphoryl threonine and serine methyl esters (Sa and 5b) underwent the intramolecular catalyzed hydrolysis reaction.

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