Synthesis and Neurotropic Activity of 2,4-pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d] Pyrimidines

Abstract

2,4-Disubstituted derivatives of pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d] pyrimidines were synthesized and their pharmacological studies was carried out at animals by the tests of antagonism with subcutaneous administration of corazol and behavior of "open field" model. The method of "rotating rod" was used to evaluate of neurotoxicity. The neurotropic properties were found in the new synthesized compounds. The new synthesized compounds as well as diazepam prevented the occurrence of clonic twitchings and clonic corazol seizures in animals. However, the studied compounds in contrast of tranquilizer diazepam having the anxiolytic and activating effects in the test of "open field", induced a oppressive behavior sedative effects.