Abstract
Abstract 5′-[Bis (2—chloroethyl) amino]—5′-deoxy uridine (uri-dine mustard), compound 5, was synthesized and characterized by its 1H, 13 C, and two-dimensional homonuclear shift correlated (COSY) and two—dimensional heteronuclear correlated NMR spectra. In comparative murine studies, uridine mustard was substantially less leukopenic than the equitherapeutic dose of uracil mustard.
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