Abstract
This paper highlights the benefits resulting from the application of double active pharmaceutical ingredient in ionic liquids as active pharmaceutical ingredients (APIs). Double active pharmaceutical ingredient benzalkonium ibuprofenate with anti-bacterial and anti-inflammatory roles, which offers high solubility, bio-availability, and biological activity. Structure and vibrational properties of NaIb, BaCl, and synthesized BaIb have been studied using Density Function Theory and are in good agreement with the experimental results of FTIR, UV–Visible, and NMR. The thermal and spectroscopic investigation using differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS) revealed different phases of BaIb and disclosed the synthesized API is an excellent glass former. The glass transition temperature Tg=194.14K and fragility index m=68.58 were estimated and compared with other members of the profen's family by Vogel–Fulcher–Tamman (VFT) equation. Finally, the in vitro and in vivo biological activities of the synthesized drug BaIb were done along with the parent drugs NaIb and BaCl as a control to ensure the double active effect.
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