Synthesis and molecular docking of novel fluorescent alkoxy-substituted iodobiphenyl analogues.

Abstract

New fluorescent iodobiphenyl ethers bearing para-alkyloxy functional group of diverse alkyl tail lengths. The synthesis process was simply accomplished via alkali-assisted reaction of aliphatic alcohols with hydroxyl-substituted iodobiphenyls. The molecular structures of the prepared iodobiphenyl ethers were determined by FTIR, elemental analysis and NMR spectroscopy. Both absorption and fluorescence spectra proved solvatochromic activity. The synthesised alkyloxy-substituted iodobiphenyl analogues were tested for antioxidant effectiveness using the DPPH methodology. The antioxidant outcomes demonstrated that the longest hydrocarbon chain-containing substituted iodobiphenyl analogues had a supreme efficacy over an IC50 =21.26±0.36 μg/mL. Alkyloxy-substituted iodobiphenyl analogues were also undergo docking operations over 5IKQ protein.