Synthesis and molecular and crystal structure of 3a-azonia(4-phenyl-6-methyl-4,9-dihydroquinazolino-[3a,9a]-3,10-dihydro-1H-pyrazinone-2) bromide

Abstract

Under acid-catalyzed conditions of the action of hydrogen bromide in glacial acetic acid, N-[2-(N-carbobenzoxyglycyl)-amido-5-methylbenzhydryl]glycine is converted to a quinazolinopyrazinone derivative, which is also obtained from the dihydrobromide of the methyl ester of N-(2-glycylamido-5-methylbenzhydryl)glycine in the presence of water. The indicated compounds structurally represent ortho-substituted benzene derivatives, which is responsible for the specificity of their conversion under the conditions cited. The structure of quinazolinopyrazinone was established by x-ray crystallographic analysis.