Abstract
The biomimetic organic–inorganic scaffold with the chemical composition, structural dimensions, topography, and microstructural properties that fulfills the requirements for hard-tissue engineering was developed.
Highlights
Since 1936, when poly(methyl methacrylate) was developed,[1] extensive studies have led to the preparation of its various derivatives, including poly(3-(trimethoxysilyl)propyl methacrylate), poly(2-hydroxyethyl methacrylate), etc., and to the discovery of many useful commercial applications of these polymers, such as energy storage, highperformance engineering plastics, functional coatings, and biomaterials.[2]
Spectra were referenced to the residual solvent signals (DMSO-d6 2.50, CDCl3 7.26, HOD 4.79 for D2O ppm) as an internal reference. 13C Nuclear magnetic resonance (NMR) spectra were collected at 125.77 MHz with a relaxation delay of 2.0 s and a pulse width of 15 and referenced to solvent signals ((13CH3)2SO 39.52, 13CDCl3 77.16 ppm). 29Si NMR spectra were recorded on a Bruker AMX-300 spectrometer using Wildmad PTFE–FEP 5 mm tube liners and were collected at 59.62 MHz with a relaxation delay of 10.0 s and a pulse width of 13
In the rst approach, we prepared a tri uoromethanesulfonate– polyhedral oligomeric silsesquioxanes (POSS) salt [OAS-POSS-NH3]CF3SO3 that was used for further synthesis of an octafunctionalized POSS derivative based on 3-(trimethoxysilyl)propyl methacrylate. [OAS-POSS-NH3]CF3SO3 was obtained in hydrolytic condensation using (3-aminopropyl) triethoxysilane (APTES) and 1.5 equivalents of tri uoromethanesulfonic acid (CF3SO3H) (Scheme 1)
Summary
Since 1936, when poly(methyl methacrylate) was developed,[1] extensive studies have led to the preparation of its various derivatives, including poly(3-(trimethoxysilyl)propyl methacrylate) (pTMSPMA), poly(2-hydroxyethyl methacrylate) (pHEMA), etc., and to the discovery of many useful commercial applications of these polymers, such as energy storage, highperformance engineering plastics, functional coatings, and biomaterials.[2] Such polymers and their composites have a longestablished role in medicine as restorative agents in the fabrication of dental composites, contact lenses, drug release systems, arti cial skin, bone cements, and other tissue engineering scaffolds.[3,4,5,6,7,8,9] Besides the many advantages of these type of polymer materials, there are noticeable usage drawbacks, which inter alia include high viscosity, large polymerization shrinkage, and poor mechanical properties From this point of view, considerable attention has been directed to materials that will bypass such disadvantages. Copolymers based on polyhedral oligomeric silsesquioxanes (POSS) occupy a special position.
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