Abstract
The synthesis of DNA and the metabolism and synthesis of DNA precursor compounds in human leukocytes are reviewed. Despite the difficulties from in-complete information on leukocytes only data from leukocyte systems have been employed. Emphasis is placed on: (1) control mechanisms; (2) pathways and enzymes that appear to be the most relevant to chemotherapy of leukemia; (3) some of the technical problems and difficulties in interpretation of data in a heterogeneous cellular system; (4) enzymatic quantitative changes during leukocyte maturation; (5) the control and alternate routes for synthesis of thymidylate, the key DNA precursor; and (6) on recent information, particularly regarding DNA polymerase(s)
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