Synthesis and magnetic resonance studies of some phosphinous acids, phosphorylacetic acids, and some of their coordination compounds

Abstract

The synthesis of phosphorylacetic acids, RR′P(O)CH 2COOH, where R = C 6H 5 and R′ = OC 2H 5, C 2H 5, i-C 3H 7, n-C 4H 9, sec-C 4H 9 and C 6H 5, from the appropriate phosphinous acids, several of which are previously unreported, is discussed. 31P nuclear magnetic resonance spectra are reported for the phosphinous acids, RR′P(O)H, the phosphorylacetic acids and the metal derivatives of the phosphinous acids, RR′POM, where M in Na or MgBr, which are intermediates in the synthesis. The diastereoisomers of Ph sec-BuP(O)H exhibit different 31P NMR spectra. Diastereotopic protons of the phosphinous acids and phosphorylacetic acids do not exhibit complex PMR spectra, whereas the diastereotopic methyl groups of the isopropyl compounds do. Some metal complexes of the phosphorylacetic acids are reported.