Abstract
Two new Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O were synthesized from DTPA-bis(amide) conjugates of arylpiperazinyl amines. The relaxivity (R1) of these complexes was measured in deionized water, which revealed that complex 2 had a higher relaxivity than 1 and Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of 1 and 2 indicated that they are non-toxic which warrant their physiological suitability as potential contrast agents for MRI. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods including elemental analysis, 1H NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.
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