Abstract
Abstract A series of bis-hydroxamic acids was prepared by the condensation of the aminoacids glycine, β-alanine, and γ-aminobutyric acid, with succinyl and adipoyl chlorides followed by conversion of the terminal carboxyl groups to hydroxamic acids (HA). Mole ratio plots of iron chelation indicated that 3:1 HA: Fe complexes exist at pH 4 and 6, but that 2:1 HA: Fe complexes are the prevalent species at pH 2. Differences in spacing had little effect on the iron complexing ability as measured through competition equilibria with EDTA. The six bis-hydroxamic acids were subjected to a bioassay screen designed to select compounds possessing in vivo iron removal activity for potential use in treating iron overload in Cooley′s Anemia. All of the six compounds had some activity. The bis-hydroxamic acid derived from succinic acid and γ-aminobutyric acid was particularly active, almost as active as the standard drug desferrioxamine-B.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
