Abstract
A series of 3(5)-substituted 1,2,4-triazole-5(3)-carboxylic acid amides, hydroxamic, hydrazide, iminosemicarbazide, semicarbazide and thiosemicarbazide have been synthesized. Most of the prepared compounds were tested for their growth inhibitory activity against Staph. aureus and E. coli and none of them revealed antibacterial activity at concentration up to 2.5 mg/mL. The 5(3)-iminosemicarbazides (8h, 9h, 10h, 11h), 5(3)-semicarbazides (8i, 9i, 10i, 11i) and 5(3)-thiosemicarbazides (8j, 9j, 10j) were chosen for evaluation of their potentialities to lower blood glucose level in rats. The oral glucose tolerance test was used as preliminary test for evaluation of hypoglycemic activity of these compounds. The tested compounds showed different onset and duration of action.
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