Abstract
Multiple antibiotic resistance has now become a major obstacle to the treatment of infectious diseases. In this context, the application of nanotechnology in medicine is a promising alternative for the prevention of infections with multidrug-resistant germs. The use of silver as a powerful antibacterial agent has attracted much interest. TiO2 and SiO2 thin films enhanced with Ag particles have been developed with the aim of maintaining the transparency of the polymer films. Antibacterial activity was evaluated for a Gram-negative species-Escherichia coli-in concentrations of 105 and 104 CFU/mL in different conditions-activation by UV irradiation, single layer and double layer. Increased antibacterial efficacy of TiO2-deposited foil was found for the tests that had been exposed to UV activation. In the case of bilayer tests, the efficiency was higher compared to those in a single layer, as the contact surface between the films and the bacterial suspension increased. Films can be used as a potential method to limit bacterial growth on hospital surfaces, such as telephone screens and medical equipment, given their optimized characteristics and proven antibacterial efficacy.
Highlights
IntroductionFaculty of Civil Engineering, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania; Abstract: Multiple antibiotic resistance has become a major obstacle to the treatment of infectious diseases
Faculty of Medicine, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania; National Institute of Research and Development for Optoelectronics-INOE 2000, 077125 Magurele, Romania; Physical Materials Science and Composite Materials Centre, Research School of Chemistry & Applied
The aim of this study is to evaluate the antibacterial activity of polyurethane selfadhesive foils coated by TiO2 and SiO2 thin films enhanced with silver particles, in various conditions such as UV exposure and film doubling, to improve antimicrobial efficiency, as a potential material to protect screens used in medical environments
Summary
Faculty of Civil Engineering, Transilvania University of Brasov, B-dul Eroilor nr 29, 500036 Brasov, Romania; Abstract: Multiple antibiotic resistance has become a major obstacle to the treatment of infectious diseases. In this context, the application of nanotechnology in medicine is a promising alternative for the prevention of infections with multidrug-resistant germs. Increased antibacterial efficacy of TiO2 -deposited foil was found for the tests that had been exposed to UV activation. Antibiotic resistance of many pathogens has been constantly increasing, becoming a major threat to global public health [3]. Data collected by the European Antimicrobial Resistance Surveillance Network (EARS-Net) in
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