Abstract
A convenient synthesis of a thymidine (T) nucleoside dimer (T-3′-CH 2-O-NCH 3-5′-T) 12 has been accomplished via a nucleoside coupling reaction. An alternative synthesis of 3′-deoxy-3′- C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides.
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