Abstract
The synthesis of optically pure long-chain 2-amino-alcohols and 1- O-dodecyl-2-deoxy-2-amino- sn-glycerol was carried out starting from l- or d-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED 50 from 0.017 to 0.010 mmol/kg).
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