Abstract
Four N-substituted amide derivatives of sorbic acid and two amine salts of sorbic acid were synthesized and tested for fungistatic activity against Microsporum canis, Trichophyton mentagrophytes, and Candida albicans. The compounds were tested by the disk-plate method initially and then followed by incorporation into polyethylene glycol ointment USP and tested on Sabouraud's dextrose agar culture plates. Results were compared with undecylenic acid and sorbic acid controls. The disk-plate method showed activity greater than sorbic acid, but less than undecylenic acid only for N-methylfurfurylsorbamide when tested against Microsporum canis and Trichophyton mentagrophytes. When incorporated into ointment, both N-methylfurfurylsorbamide and t-octylamine sorbate showed activity comparable to the controls against Microsporum canis and Trichophyton mentagrophytes. None of the new compounds were as effective against Candida albicans as were the controls.
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