Abstract
A simple, straightforward, and highly efficient one-pot three-component synthesis of a pharmaceutically interesting kind of functionalized dihydro-6H-chromeno[4,3-b]isoxazolo[4,5-e]pyridine heterocycles has been developed based on an environmentally benign method. All synthesized compounds were evaluated for their antidiabetic activity against type 2 diabetes mellitus. The results indicated that most of the synthesized compounds exhibited moderate to good antidiabetic activity. Synthesized compound 4i demonstrated the highest inhibition of α-amylase activity (IC50 = 56.043 µg/mL). This finding suggests an approach to develop effective antidiabetic agents by incorporating pyridine core structure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
